Pycnogenol® Supplementation Improves The Control Of Irritable Bowel Syndrome Symptoms

Effect Decrease
Trial Design Uncontrolled / observational study
Trial Length 2-4 Weeks
Number of Subjects 77
Sex Female
Age Range 30-44
Body Types Average
Notes for this study:
Although promising, this study should be interpreted with caution, as it lacked a blinded approach or placebo-control. 77 otherwise healthy subjects with IBS were divided into 3 groups in an open-label study design. Group 1 took 10 mg Buscopan, an antispadmodic, as needed. Group 2 took Antispasmina col forte, another antispasmod consisting of 50 mg papaverine hydrochloride+10 mg belladonna extract also when needed. The third group took pycnogenol at a dosage of 150 mg/ day for 3 weeks. Although the number of painful bowel attacks were similar in all groups after 4 weeks, mild pain and abdomen pressure was decreased in all the treatment groups. Improvement of pain symptoms was significantly greater in the pycnogenol groups relative to the other treatment groups, however. This indicates that pycnogenol may be a useful as a treatment for IBS symptoms.