Studies related to NF-kB Activity and Pycnogenol

Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)
Effect Decrease
Trial Design cohort
Trial Length 1week
Number of Subjects 7
Sex mixed
Notes for this study:
In 7 otherwise healthy adults given 200mg pycnogenol for 5 days with a semi-controlled diet, supplementation was able to reduce circulating levels of MMP9 (an inflammatory biomarker) and reduce nF-kB activity. Although all subjects noted benefits, they were somewhat variable.
Funding issues for this study:
Funded by Horphag Research and a VEGA grant, no known conflicts of interest