Studies related to Symptoms of Narcolepsy and L-Tyrosine

Treatment Of Narcolepsy With L-tyrosine: Double-blind Placebo-controlled Trial

Effect None
Values Mean and SEM. Sleep paralysis. # of attacks/wk. Before 1.9 (3.1). Placebo: 2.2 (2.6) Tyrosine: 2.5 (2.9). Cataplexy. Number of attacks/day. Before: 4.2 (4.5) Placebo: 4.5 (3.0)Tyrosine: 3.4 (2.9) . Narcolepsy severity rating. Placebo: 2.7 (1.4). Tyrosine: 3.0 (1.6). Daytime sleep. No of naps./d. Before: 3.5 (1.9) Tyrosine: 4.1 (3.0) Placebo: 3.9 (2.1) Duration (min) Before: 88.3 (59) Tyrosine: 99.5 (52.0) Placebo: 101.8 (44 99.5 (52.0 No of half-asleep periods per waking day. Before: 2.9 (2.2)Tyrosine: 2.8 (2.1) Placebo: 2.6 (2.2)
Trial Design Randomized trial
Trial Length 2-4 Weeks
Number of Subjects 10
Sex Both Genders
Notes for this study:
In a randomized, double-blind, placebo-controlled crossover trial, 10 participants with narcolepsy took 9 g of tyrosine or placebo for 4 weeks before crossing over with no washout period.

Participants rated themselves as being less tired, less drowsy, and more alert when taking tyrosine. There weren't statistically significant differences in mood. However, there weren't statistically significant differences in cognitive performance, cataplexy, sleep paralysis, daytime sleep, night-time sleep duration, number of wakings, or sleep latency.