Studies related to Inflammation and Stinging Nettle

Cytokine Secretion In Whole Blood Of Healthy Subjects Following Oral Administration Of Urtica Dioica L. Plant Extract

Effect Decrease
Trial Design Cohort
Trial Length 2-4 Weeks
Number of Subjects 20
Gender Both Genders
Age Range 18-29, 30-44
Notes for this study:
Oral ingestion of Stinging Nettle was able to reduce the amount of TNF-a (a pro-inflammatory biomarker and cytokine) released in response to lipopolysacchrade (LPS).

A release of IL-6 was seen when LPS was not present, but did not occur with LPS present and thus was not overly inflammatory.

The Effect Of Hydro Alcoholic Nettle (Urtica Dioica) Extracts On Insulin Sensitivity And Some Inflammatory Indicators In Patients With Type 2 Diabetes: A Randomized Double-blind Control Trial

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 50
Gender Both Genders
Age Range 30-44, 45-64
Body Types Overweight
Notes for this study:
Subjects received 100mg/kg Nettle Root (hydroalcoholic extract) daily for 8 weeks, had the pre-existing state of type II diabetes.

IL-6, a biomarker for inflammation, decreased along with C-reactive protein over the 8 week supplementation period. No effect on TNF-a reached significance due to variation at baseline and in control.

Weight and BMI as well as Insulin Sensitivity (measured by the Katz equation of fasting glucose and insulin (PMID:10902785)) were unchanged.