Studies related to Immunoglobulin A and Colostrum

IGF-I, IgA, And IgG Responses To Bovine Colostrum Supplementation During Training

Effect Increase
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 30
Gender Both Genders
Age Range 18-29
Body Types Average
Notes for this study:
Supplementation of 20g colostrum (4.8g immunoglobulins and 74mcg IGF-1) for two weeks in healthy adults is able to increase IGF-1 concentrations by 17%, but this does not appear to be related to oral consumption of IGF-1 in the product (as it is hydrolyzed).

Salivary, but not serum, IgA was increased 33% and IgG was not affected despite oral ingestion of 4.5g IgG (0.3g IgA).

Effects Of Bovine Colostrum Supplementation On Immune Variables In Highly Trained Cyclists

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 29
Gender Male
Age Range 18-29, 30-44
Body Types Trained, Average
Notes for this study:
Supplementation of 10g bovine colostrum (20% Immunoglobulin G) failed to influence neutrophil adhesion factors (CD89) or surface markers on NK cells or lymphocytes. The expected decrease in CD3+CD8+ T cells seen with exercise, however, was attenuated relative to whey protein control resulting in a lesser reduction in the CD4/CD8 ratio associated with intense exercise.

The increase seen in salivary IgA with colostrum failed to reach statistical significance; total IgA and IgE in serum were unaffected. Overall rates of sickness trended to be reduced, but this did not reach significance.

The Effect Of Bovine Colostrum On Viral Upper Respiratory Tract Infections In Children With Immunoglobulin A Deficiency

Effect None
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 32
Gender Both Genders
Age Range 7-12, 13-17
Body Types Average
Notes for this study:
Supplementation of colostrum (14mg sucking tablet) in children with IgA deficiency noted that infection and sickness severity (from viral URTIs) was significantly reduced (via parental report) relative to placebo after one week. This was not associated with salivery IgA, as colostrum failed to increase this parameter after one week.

A Pilot Study: Bovine Colostrum Supplementation And Hormonal And Autonomic Responses To Competitive Cycling

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 10
Gender Male
Age Range 18-29, 30-44
Body Types Trained, Average
Notes for this study:
While 10g colostrum (relative to the placebo of 10g whey protein) did not influence baseline testosterone when supplemented by elite male cyclists over eight weeks, the expected reduction in testosterone seen during a five day road race was attenuated and the circadian rhythm of testosterone (which was normalized in control) was preserved.

Cortisol was increase in morning salivary measurements on the first day of the race (no influence on nightly readings), and IgA was no influenced in the saliva under any context.

The Effect Of Bovine Colostrum Supplementation On Salivary IgA In Distance Runners

Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 35
Gender Both Genders
Age Range 30-44, 45-64
Body Types Trained, Average
Notes for this study:
In long distance runners, supplementation of colostrum powder at 26g daily for 14 weeks (placebo of skin milk) noted an increase in salivary IgA of 79% (relative to a 12% increase seen with placebo) noted at 12 weeks (but not 4 nor 8).

Effect Of Bovine Colostrum Supplementation On Respiratory Tract Mucosal Defenses In Swimmers

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 43
Gender Both Genders
Age Range 18-29
Body Types Trained, Untrained, Average
Notes for this study:
Supplementation of colostrum (50g taken in two doses daily; about 3% IgG) in both athletes and sedentary persons for 10 weeks failed to influence both salivary and serum concentrations of IgA, IgM, and IgG; while it appeared that there were less upper respiratory tract symptoms in the latter half of the study with colostrum this did not reach significance.

Modulation Of Human Humoral Immune Response Through Orally Administered Bovine Colostrum

Effect Increase
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 18
Gender Both Genders
Age Range 18-29, 30-44, 45-64
Notes for this study:
In otherwise healthy adult volunteers given 100mL of a colostrum beverage (Bioenervi) for one week where vaccination capsules were also ingested thrice, supplementation appeared to augment the vaccine induced elevations of IgA and IgG, but not IgM, specific to the vaccine despite the total immunoglobulin secreting cells not being altered nor their receptors.

Bovine Colostrum Supplementation's Lack Of Effect On Immune Variables During Short-term Intense Exercise In Well-trained Athletes

Effect None
Trial Design Double blind
Trial Length 1-2 Weeks
Number of Subjects 9
Gender Male
Age Range 18-29
Body Types Trained, Average
Notes for this study:
Supplementation of colostrum at 25g daily (two doses) with a high IgG content (65g/L) for ten days in which the last two days were a glycogen depletion trial followed by an endurance trial (90m at 50% Wmax) failed to alter performance during the glycogen depletion trial (anaerobic), failed to alter immune cell changes during exercise, immunoglobulins in serum, or any measured interleukin or cytokine relative to placebo (skim milk).