Manipulation Of Dietary Short Chain Carbohydrates Alters The Pattern Of Gas Production And Genesis Of Symptoms In Irritable Bowel Syndrome
Notes for this study:
||On the low-FODMAP diet, breath hydrogen production was significantly lower in both healthy participants (43 ± 18 versus 181 ± 77 ppm, p<0.0001) and participants with IBS (62 ± 23 versus 242 ± 79 ppm, p<0.0001).
|Number of Subjects
||18-29, 30-44, 45-64, 65+
In this randomized, crossover trial, 30 participants (15 healthy and 15 with IBS) consumed a provided low-FODMAP or high-FODMAP diet for 2 days. Participants recorded dietary intake and gastrointestinal symptoms, and breath samples were collected hourly for 14 hours on day 2 of each diet.
Funding issues for this study:
Breath hydrogen production was higher in all participants on the high-FODMAP diet compared to the low-FODMAP diet. Participants with IBS produced more breath hydrogen than healthy participants on both diets. Breath methane was reduced in healthy participants during the high-FODMAP diet, but didn't change in participants with IBS. A composite IBS symptom score that included abdominal pain, bloating, and flatulence (wind) was higher in IBS patients during the high-FODMAP diet. In healthy participants, this score was also higher during the high-FODMAP diet, but due only to increased flatus. Individuals with IBS also reported more severe lethargy and heartburn during the high-FODMAP diet.
There was no association between the pattern of methane or hydrogen production with the induction of symptoms.
The author has published cookbooks and shopping guides concerning low-FODMAP foods and coeliac disease.