Efficacy Of Methylsulfonylmethane Supplementation On Osteoarthritis Of The Knee: A Randomized Controlled Study

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 50
Sex Both Genders
Age Range 65+
Body Types Obese, Overweight
Notes for this study:
MSM supplementation at 3.375g daily for 12 weeks was associated with overall improvements in the symptoms of osteoarthritis and although a pain reducing effect was apparent it was so variable it failed to reach statistical significance. Perhaps the most marked difference was a reduction of stiffness by 26% in MSM while placebo increased 37%, but this was also so variable that it failed to reach significance.

There were some differences (gender and BMI) between groups at baseline, although the MSM group tended to weigh more.