| Effect | Increase |
| Trial Design | Double blind |
| Trial Length | 1-6 months |
| Number of Subjects | 153 |
| Gender | Both Genders |
| Age Range | 18-29, 30-44, 45-64 |
| Body Types | Obese, Overweight |
Three groups were created; Cissus, CORE (Cissus + Green Tea + Soy albumin, chromium, and B-vitamins). Cissus was supplied at 2.5% ketosteroids, or 15mg daily. CORE was further divided into dietary intervention (2100kcal) or no dietary restrictions.
The group that took in Cissus itself at 300mg daily experienced a significant drop in weight (118.6kg to 113.8kg over 6 weeks) and a non-significant reduction in fat mass. This was in conjunction with a 2100kcal diet.
Significant decreases in total cholesterol and TGs were noted, LDL-C did not reach significance.
Increases were seen in plasma serotonin and creatinine, and a decrease in Malondialdehyde (MDA, biomarker for lipid peroxidation) was seen.