| Effect | Increase |
| Trial Design | Double blind |
| Trial Length | 1-6 months |
| Number of Subjects | 23 |
| Gender | Both Genders |
| Age Range | 18-29 |
Chewing a gum containing two different strains of _l. reuteri_ (2x10^8^ CFU, twice daily) including ATCC 55730 and ATCC PTA 5289 over the course of 12 weeks appears to have no influence on total IgA concentrations, but increased the percentage of total protein that was IgA (13.5%).
Antibodies for bacteria in the oral cavity was altered in a manner thought to be indicative of improved dental health (reduced _s.mutans_ and increased _lactobacillus_).