| Effect | Decrease |
| Trial Design | Double blind |
| Trial Length | 1-6 months |
| Number of Subjects | 734 |
| Sex | Both Genders |
| Age Range | 45-64, 65+ |
1200mg SAMe after 30 days was associated with significant improvements in pain and functionality in adults with osteoarthritis. Efficacy was similar to 750mg Naproxen in regards to pain reduction and symptoms reduction over 30 days. There was efficacy in persons with hip osteoarthritis
