Kefir Consumption Does Not Alter Plasma Lipid Levels Or Cholesterol Fractional Synthesis Rates Relative To Milk In Hyperlipidemic Men: A Randomized Controlled Trial [ISRCTN10820810]

Effect None
Trial Design Randomized trial
Trial Length 2-4 Weeks
Number of Subjects 13
Sex Male
Age Range 18-29, 30-44, 45-64
Notes for this study:
In this small crossover trial of 13 men with high total serum cholesterol (between 6 and 10 mmol/L), participants received 500 mL/day of kefir (treatment) or milk (control) for 4 weeks, then after a 4-week wait received the other (ie. got milk if they'd previously gotten kefir, or vice versa). There was no significant decrease in total cholesterol, HDL, LDL, or triglycerides after either milk or kefir supplementation, and no significant difference in cholesterol fractional synthesis rate between milk and kefir groups. There was no significant change in serum fatty acid levels after either kefir or milk supplementation, but both kefir and milk supplementation significantly increased fecal isobutyric, isovaleric and propionic acids as well as the total amount of fecal short chain fatty acids. Significantly more participants had greater fecal bacterial concentration after kefir supplementation than after milk supplementation.