| Effect | None |
| Trial Design | Randomized trial |
| Trial Length | n/a |
| Number of Subjects | 40 |
| Sex | n/a |
Colorectal cancer patients undergoing six cycles of 5-FU chemotherapy were given either kefir mouthwash + drink (250 ml 2x/day), or saltwater mouthwash (control). There was no significant difference in the incidence of oral mucositis (acute inflammation of the oral mucous membranes, a common side effect of chemotherapy). The study also compared the serum proinflammatory cytokine levels (TNF-alpha, IL-1beta and IL-6) of the two groups, and found no significant difference.Funding issues for this study:
Note: the kefir used in this study was prepared in-lab from kefir grains. The bacteria and yeasts in this kefir weren't identified in the study.
Funding not declared
