Studies related to Bone Mineral Density and Kefir

Short-Term Effects Of Kefir-Fermented Milk Consumption On Bone Mineral Density And Bone Metabolism In A Randomized Clinical Trial Of Osteoporotic Patients

Effect None
Values No significant difference between control and kefir. Large loss to follow-up + irregularities in study registration, analysis and reporting => weak evidence.
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 40
Sex Both Genders
Age Range 45-64, 65+
Notes for this study:
In this registered clinical trial of patients with osteoporosis, the experimental group (24 participants) was given 1600 mg/day of kefir and a calcium supplement for 6 months, while the control group was given unfermented milk and the same calcium supplement. The average bone mineral density increased in both groups, but the difference between control and kefir wasn't significant. The study took blood samples before, during and after the intervention, and found weak evidence for some differences between the kefir group and the control group. However, a lot of irregularities in how this study was registered, analyzed, and reported, coupled with a large loss to follow-up, make this study very weak evidence for any beneficial effects of kefir. Future research is needed to explore this issue.
Funding issues for this study:
No conflicts of interest declared. "This research was supported in part by grants NSC-99-2324-B-005-017-CC1, NSC-101-2324-B-005-002-CC1, MOST-101-2313-B-005-014-MY3, and MOST-104-2313-B-005-043-MY3 from the National Science Council and the Ministry of Education, Taiwan, Republic of China, under the Aiming for the Top University plan (ATU-103-S0508). The funders had no role in this design, data collection and analysis, decision to publish, or preparation of the manuscript."