Studies related to Dyschezia and Melatonin

Efficacy Of Melatonin In The Treatment Of Endometriosis: A Phase II, Randomized, Double-blind, Placebo-controlled Trial

Effect Decrease
Values Melatonin group reported 2.2 points lower pain scores during defecation on a 0-10 visual pain scale (placebo average 6.3, melatonin average 4.1).
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 40
Sex Female
Age Range 18-29, 30-44, 45-64
Notes for this study:
40 Brazilian women with endometriosis-associated chronic pelvic pain (EACPP) were randomized to take 10mg melatonin or placebo for 8 weeks. The melatonin group self-reported significantly less: overall pain, pain during menstruation, pain during sex, and use of analgesics (primary outcomes). They also self-reported significantly less pain while urinating and defecating, and better sleep (secondary outcomes). The study also measured blood BDNF levels and found that they were significantly lower in the melatonin group.
Funding issues for this study:
None declared.