Studies related to Bilirubin and Vitamin B3 (Niacin)

Short-term Effects Of Extended-release Niacin With And Without The Addition Of Laropiprant On Endothelial Function In Individuals With Low HDL-C: A Randomized, Controlled Crossover Trial

Effect Increase
Trial Design Randomized trial
Trial Length 1-7 Days
Number of Subjects 18
Sex Both Genders
Age Range 18-29, 30-44, 45-64
Notes for this study:
Supplementation of 1g extended release niacin for one week in subjects with low HDL cholesterol appeared to beneficially influence triglycerides to a minor degree (3-4%) without affecting HDL quantity, although particle size of HDL was decreased in both groups (5.8-6.2%; with or without laropiprant).

There appeared to be an improvement in flow-mediated vasodilation that was dependent on supplementation, as it was no longer present a week after supplementation was ceased.