Studies related to Insulin Secretion and Vitamin B3 (Niacin)

Impaired Beta-cell Function In Human Aging: Response To Nicotinic Acid-induced Insulin Resistance

Effect Decrease
Trial Design Double blind
Trial Length 1-2 Weeks
Number of Subjects 45
Sex Both Genders
Age Range 18-29, 30-44, 65+
Notes for this study:
In three groups of subjects (youth, aged, and aged with impaired glucose tolerance) the addition of 500mg niacin, titrated up to 1000mg, for two weeks appeared to cause an increase in serum glucose and insulin thought to be initially due to an impairment of pancreatic beta cells to 'sense' glucose and secrete insulin in response; the recomponsation over two weeks being insufficient to normalize glucose.

This study also used aspirin in both groups in an attempt to reduce the niacin flush.