Conjugated Linoleic Acid Modulates Immune Responses In Patients With Mild To Moderately Active Crohn's Disease
Notes for this study:
|Number of Subjects
6g of supplementation (77% CLA by weight; 1:1 ratio of the two main isomers) for 12 weeks noted significant improvements in quality of life () associated with supplementation (pilot study, no placebo group). The benefit seen according to CDAI rating was 13.1% at week 6 and 23.6% at 12 weeks with the authors suggesting that it may not be clinically significant.
Secretion of IL-2 increased from isolated CD4+ and CD8+ lymphocytes, while serum IL-6 was higher after 12 weeks. IL-8, IL-1β, IL-10, TNF-α, or IL-12p70 were all unaffected, and lymphocyte secretion of TNF-α and IFNy was reduced.