Effects Of Curcuminoids Plus Piperine On Glycemic, Hepatic And Inflammatory Biomarkers In Patients With Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial

Effect None
Values HOMA-IR. Placebo: before 3.2 ± 0.5, after 3.1 ± 0.4. Curcumin: before 8.1 ± 2.1, after 7.4 ± 2.0
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 118
Sex Both Genders
Age Range 18-29, 30-44, 45-64, 65+
Body Types Obese, Overweight, Average, Underweight
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 118 participants with type 2 diabetes were assigned to take either placebo or 500 mg of curcuminoids with 5 mg of piperine daily for 3 months.

25% of participants failed to complete the trial. Compared with the placebo group, the curcumin group saw a statistically significant reduction in weight/BMI, fasting glucose, HbA1c, c-peptide, ALT, and AST. There was no statistically significant difference for insulin, hd-CRP, creatinine, HOMA-IR, HOMA-B, or hepatic steatotic index.

When grouped by gender, males had a statistically significant decrease in glucose but not females, and females had a statistically significant decrease in HbA1c and AST but not males.
Funding issues for this study:
Conflict of interest: "Muhammed Majeed is the Founder & Chairman of Sabinsa Corporation
and Sami Labs Limited."

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