Influence Of Enhanced Bioavailable Curcumin On Obesity-associated Cardiovascular Disease Risk Factors And Arterial Function: A Double-blinded, Randomized, Controlled Trial

Effect Increase
Values Total antioxidant capacity - CRE (µM). Placebo: before 9719 ± 506, after 9970 ± 499. Curcumin: before 8956 ± 1051, after 9885 ± 806. UAE. Placebo: before 4.44 ± 0.23, after 4.55 ± 0.23. Curcumin: before 4.09 ± 0.48, after 4.52 ± 0.37
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 22
Sex Male
Age Range 18-29, 30-44
Body Types Obese
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 22 obese but healthy, male participants were assigned to take 193.0 mg of curcuminoids infused into 60% soluble fiber from fenugreek, or the fenugreek fiber alone, daily, for 12 weeks.

There was a statistically significant reduction for the curcumin group in homocysteine and an increase in HDL compared with placebo. There was no statistically significant difference between groups at the end of 12 weeks for fasting glucose, insulin, leptin, adiponectin, antioxidant capacity as assessed by uric acid equivalents or copper reducing equivalents, LDL, or any measure of endothelial function or blood pressure.

No adverse events were reported.

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