| Effect | None |
| Trial Design | Double blind |
| Trial Length | 1-2 Weeks |
| Number of Subjects | 19 |
| Sex | Both Genders |
| Age Range | 30-44, 45-64 |
| Body Types | Overweight |
In essential hypertensives with impaired glucose tolerance given 50g of dark chocolate (1009mg phenols, 111mg epicatechin) twice a day for 15 days improved blood pressure (systolic, diastolic, and ambulatory) and improved insulin sensitivity as assessed by QUICKI and HOMA-IR; an improvement in beta-cell function appeared to also exist alongside modest improvements in cholesterol.Funding issues for this study:
Blood flow (FMD) improved, but other serum parameters related to inflammation and methylation did not.
Napoleone Neri, Chairman, Sugar Company donated the chocolate bars, but had no part in funding; funding by USDA
