Studies related to C-Reactive Protein and Hesperidin

Hesperidin Contributes To The Vascular Protective Effects Of Orange Juice: A Randomized Crossover Study In Healthy Volunteers

Effect None
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 24
Gender Male
Age Range 45-64
Body Types Overweight
Notes for this study:
In otherwise healthy overweight men, consumption of either orange juice or a control drink with pure hesperidin as a pill (with a third double-placebo group) noted that hesperidin at 292mg, relative to placebo over four weeks, was able to decrease diastolic blood pressure (3.2+/-1.5mmHg; 3.7%) with no influence on any other measured parameter except uric acid () and a trend to reduce sCAM-1 and increase nitric oxide.

There was no significant influence on basal microcirculation, but an increase was noted with both orange juice and hesperidin when measured acutely (6 hours after ingestion, near peak blood levels).

Effects Of Alpha-glucosylhesperidin, A Bioactive Food Material, On Collagen-induced Arthritis In Mice And Rheumatoid Arthritis In Humans

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 19
Gender Both Genders
Age Range 45-64, 65+
Notes for this study:
Supplementation of three grams (3,000mg) of G-Hesperidin in the morning for three months in persons with rheumatoid arthritis was able to increase the end point (20% improvement in three of five rating scales) from 10% to 33%, and there was a mild whole-group benefit to symptoms seen with hesperidin. There also appeared to be sporadic decreaes in C-reactive protein.

Citrus Polyphenol Hesperidin Stimulates Production Of Nitric Oxide In Endothelial Cells While Improving Endothelial Function And Reducing Inflammatory Markers In Patients With Metabolic Syndrome

Effect Decrease
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 24
Gender Both Genders
Age Range 45-64
Body Types Obese
Notes for this study:
500mg of hesperidin daily for three weeks in persons with metabolic syndrome (in a double blind crossover study) was able to significantly improve blood flow as assessed by flow mediated vasodilation (24.5%) as well as inflammatory biomarkers such as C-reactive protein (33%), serum amyloid A (23%), and E-selectin (13%) while there was no influence on blood pressure, VCAM-1, or ICAM and a minor decrease in Apolipoprotein B (2.3%) while the increase in insulin sensitivity measured at less than 1% as assessed by QUICKI failed to reach significance (P=0.06)