Studies related to Weight and Hesperidin

The Citrus Flavonoids Hesperidin And Naringin Do Not Affect Serum Cholesterol In Moderately Hypercholesterolemic Men And Women

Effect None
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 194
Gender Both Genders
Age Range 30-44, 45-64, 65+
Body Types Overweight
Notes for this study:
In persons with mildly elevated cholesterol (6.18mM), hesperidin at a daily dose of 800mg (95th percentile of dietary intake) over the course of four weeks failed to significantly improve any biomarker of cholesterol or triglycerides relative to placebo; naringenin (a third group) was equally ineffective.

Citrus Polyphenol Hesperidin Stimulates Production Of Nitric Oxide In Endothelial Cells While Improving Endothelial Function And Reducing Inflammatory Markers In Patients With Metabolic Syndrome

Effect None
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 24
Gender Both Genders
Age Range 45-64
Body Types Obese
Notes for this study:
500mg of hesperidin daily for three weeks in persons with metabolic syndrome (in a double blind crossover study) was able to significantly improve blood flow as assessed by flow mediated vasodilation (24.5%) as well as inflammatory biomarkers such as C-reactive protein (33%), serum amyloid A (23%), and E-selectin (13%) while there was no influence on blood pressure, VCAM-1, or ICAM and a minor decrease in Apolipoprotein B (2.3%) while the increase in insulin sensitivity measured at less than 1% as assessed by QUICKI failed to reach significance (P=0.06)