Studies related to Insulin Sensitivity and Hesperidin

Citrus Polyphenol Hesperidin Stimulates Production Of Nitric Oxide In Endothelial Cells While Improving Endothelial Function And Reducing Inflammatory Markers In Patients With Metabolic Syndrome

Effect None
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 24
Sex Both Genders
Age Range 45-64
Body Types Obese
Notes for this study:
500mg of hesperidin daily for three weeks in persons with metabolic syndrome (in a double blind crossover study) was able to significantly improve blood flow as assessed by flow mediated vasodilation (24.5%) as well as inflammatory biomarkers such as C-reactive protein (33%), serum amyloid A (23%), and E-selectin (13%) while there was no influence on blood pressure, VCAM-1, or ICAM and a minor decrease in Apolipoprotein B (2.3%) while the increase in insulin sensitivity measured at less than 1% as assessed by QUICKI failed to reach significance (P=0.06)