| Effect | Decrease |
| Trial Design | Double blind |
| Trial Length | 1-6 months |
| Number of Subjects | 19 |
| Gender | Both Genders |
| Age Range | 45-64, 65+ |
Supplementation of three grams (3,000mg) of G-Hesperidin in the morning for three months in persons with rheumatoid arthritis was able to increase the end point (20% improvement in three of five rating scales) from 10% to 33%, and there was a mild whole-group benefit to symptoms seen with hesperidin. There also appeared to be sporadic decreaes in C-reactive protein.