| Effect | Increase |
| Trial Design | Double blind |
| Trial Length | 2-4 Weeks |
| Number of Subjects | 24 |
| Gender | Male |
| Age Range | 45-64 |
| Body Types | Overweight |
In otherwise healthy overweight men, consumption of either orange juice or a control drink with pure hesperidin as a pill (with a third double-placebo group) noted that hesperidin at 292mg, relative to placebo over four weeks, was able to decrease diastolic blood pressure (3.2+/-1.5mmHg; 3.7%) with no influence on any other measured parameter except uric acid () and a trend to reduce sCAM-1 and increase nitric oxide.
There was no significant influence on basal microcirculation, but an increase was noted with both orange juice and hesperidin when measured acutely (6 hours after ingestion, near peak blood levels).