Studies related to Microcirculation and Hesperidin

Hesperidin Contributes To The Vascular Protective Effects Of Orange Juice: A Randomized Crossover Study In Healthy Volunteers

Effect Increase
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 24
Sex Male
Age Range 45-64
Body Types Overweight
Notes for this study:
In otherwise healthy overweight men, consumption of either orange juice or a control drink with pure hesperidin as a pill (with a third double-placebo group) noted that hesperidin at 292mg, relative to placebo over four weeks, was able to decrease diastolic blood pressure (3.2+/-1.5mmHg; 3.7%) with no influence on any other measured parameter except uric acid () and a trend to reduce sCAM-1 and increase nitric oxide.

There was no significant influence on basal microcirculation, but an increase was noted with both orange juice and hesperidin when measured acutely (6 hours after ingestion, near peak blood levels).