Effects Of Zinc Supplementation On Efficacy Of Antidepressant Therapy, Inflammatory Cytokines, And Brain-derived Neurotrophic Factor In Patients With Major Depression
Notes for this study:
|Number of Subjects
||18-29, 30-44, 45-64
The addition of zinc (25mg) to SSRI antidepressant therapy, when compared to SSRI therapy with placebo, was associated with a reduction of depressive symptoms as assessed by the HDRS after 12 weeks.
This benefit was not associated with alteration sin IL-6. TNF-α, or BDNF relative to the SSRI-placebo group. BDNF failed to increase significantly since the placebo group experienced a similar increase.