Studies related to Fatigue and Zinc

Effect Of Zinc Sulfate Supplementation On Premenstrual Syndrome And Health-related Quality Of Life: Clinical Randomized Controlled Trial

Effect Decrease
Values PSST Fatigue/lack of energy. Placebo: before 72.3, after 79.6. Zinc: befor 68.6, after 51.3.
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 142
Sex Female
Age Range 18-29, 30-44
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 142 women with PMS were allocated to either 220 mg of zinc sulfate (50 mg of elemental zinc) or placebo daily from the 16th day of each menstrual cycle to the 2nd day of the next for 3 months.

On the Premenstrual Symptoms Screening Tool, anger/irritability, anxiety/tension, depressed mood, decreased interest in world activities, decreased interest in-home activities, difficulty concentrating, fatigue, insomnia, hypersomnia, feeling overwhelmed, and physical symptoms all improved in the zinc group more than the placebo group, the difference being statistically significant. In contrast, tearfulness wasn't improved. The improvement in work efficiency, relationship with coworkers, relationships with family, social life activities, and home responsibilities were all improved more in the zinc group than the placebo group, the difference being statistically significant. The improvement tended to increase each month, which likely reflects zinc status improving each month.

On the 12-item Short-Form Health Survey Questionnaire, there was a modest improvement for both physical and psychological symptoms which was statistically significant compared with placebo.