Studies related to Cocaine Addiction and CDP-choline

Short-term Treatment With Citicoline (CDP-choline) Attenuates Some Measures Of Craving In Cocaine-dependent Subjects: A Preliminary Report

Effect Decrease
Trial Design Double blind
Trial Length 1-2 Weeks
Number of Subjects 14
Gender Male
Age Range 30-44
Body Types Overweight, Average
Notes for this study:
Supplementation of 500mg CDP-choline twice daily for 2 weeks is able to reduce cravings for cocaine in persons who previously had an addiction.

Effects Of Daily Treatment With Citicoline: A Double-blind, Placebo-controlled Study In Cocaine-dependent Volunteers

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 29
Gender Both Genders
Age Range 30-44
Body Types Overweight, Average
Notes for this study:
500mg twice daily for 8 weeks in persons dependent on cocaine but not actively seeking treatment failed to outperform placebo in reducing cocaine usage and addiction. Alcohol usage appeared to be reduced with citicholine.

A Randomized, Placebo-controlled Trial Of Citicoline Add-on Therapy In Outpatients With Bipolar Disorder And Cocaine Dependence

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 44
Gender Both Genders
Age Range 18-29, 30-44
Body Types Average
Notes for this study:
In persons with cocaine dependence and bipolar disorder, supplementation of CDP-choline has failed to influence symptoms of bipolar disorder (mania and depression) but was associated with reduced occurrence of cocaine positive urine at the end of the trial (when the patients were directed to not consume cocaine).