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Studies related to Sleep Duration and Cannabis

Do Cannabis-based Medicinal Extracts Have General Or Specific Effects On Symptoms In Multiple Sclerosis? A Double-blind, Randomized, Placebo-controlled Study On 160 Patients

Effect None
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 160
Sex Both Genders
Notes for this study:
In a 6-week randomized, double-blind, placebo-controlled trial, 160 participants with multiple sclerosis took Sativex which contains 2.7 mg of THC and 2.5 mg of CBD per 100 ul spray, and were urged to titrate up slowly and to not exceed 120 mg of THC per day and no more than 20 mg in a 3 hour period.

The primary outcome was a visual analog scale score for each patient's most troublesome symptom. There was a greater improvement in the cannabis group placebo but the difference wasn't statistically significant. There was a statistically significant improvement in spasticity, Barthel ADL index, and sleep quality overall. For participants who had various primary symptoms, there was a statistically significant improvement in spasticity, but not the others, though there were general improvements. The placebo group actually saw a greater reduction in pain, though it wasn't statistically significant.
Funding issues for this study:
GW Pharma Ltd contributed to the study design and was
involved in collection of the data. Data handling and
analysis were contracted by GW Pharma Ltd to an
independent research organization.