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The Effect Of Cannabis On Tremor In Patients With Multiple Sclerosis
| Effect | Decrease |
| Values | Tapping test |
| Trial Design | Randomized trial |
| Trial Length | 1-2 Weeks |
| Number of Subjects | 14 |
| Sex | Both Genders |
| Age Range | 18-29, 30-44, 45-64 |
In a randomized, double-blind, placebo-controlled crossover trial, 14 participants with multiple sclerosis with upper limb tremors took Cannador, an ethanolic extract of cannabis Sativa standardized to 2.5 mg of THC per capsule or placebo. There was a dose-titration period of 2 weeks where participants found a stable dose, with a maximum of 0.125 mg/kg of THC twice a day. After that, participants took their stable dose for 2 weeks.
The primary outcome was the reduction in tremor index, and there wasn't a statistically significant difference. There was also no statistically significant difference for other objective symptom measures except for tapping speed, which was reduced for those who took cannabis first but not second.
