A Pilot Study Of The Effects Of Cannabis On Appetite Hormones In HIV-infected Adult Men
| Effect | Increase |
| Trial Design | Double blind |
| Trial Length | 1-7 Days |
| Number of Subjects | 7 |
| Sex | Male |
| Age Range | 45-64 |
Administration of cannabis (2% THC by weight, titrated to the personal dose maximizing pain relief and minimizing side-effects) in a blinded manner, relative to placebo, was able to increase circulating leptin (67.1%) and ghrelin (42.4%) in HIV infected men alongside a reduction in serum peptide YY (-14.2%) over the course of a week.
Ghrelin appeared to follow a dose-dependent response whereas leptin was associated with lower peaks when THC elevation in serum was increased.
