Smoked Cannabis For Spasticity In Multiple Sclerosis: A Randomized, Placebo-controlled Trial
| Effect | Increase |
| Trial Design | Randomized trial |
| Trial Length | 1-7 Days |
| Number of Subjects | 37 |
| Sex | Both Genders |
In a randomized, double-blind, placebo-controlled crossover trial, 37 participants with multiple sclerosis to smoke a cannabis cigarette once daily for three days or a placebo cigarette, with a11 days of washout in between.
The primary outcome was the change in spasticity as measured by patient score on the modified Ash-worth scale. There was a statistically significant improvement in spasticity, pain, physical performance (via walking time), and cognitive function. Fatigue was perceived to be significantly decreased, while cognitive deficits and overall symptoms weren't statistically significantly lower.
