Studies related to Working Memory and Marijuana

Opioid Antagonism Enhances Marijuana's Effects In Heavy Marijuana Smokers

Effect None
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 29
Gender Both Genders
Age Range 18-29
Notes for this study:
In a study assessing the interactions of naltrexone and marijuana, when comparing the marijuana only group against the double placebo group in heavy smokers, marijuana alone (800mg of a 3.27% THC cigarette) was insufficient to impair psychomotor performance, short term memory, or attention on computerized testing (DRT, DAT, DSST).

Peripheral effects of marijuana (heart rate) also appeared to be enhanced alongside the enhanced neurological high in these heavy users.

Marijuana's Dose-dependent Effects In Daily Marijuana Smokers

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 19
Gender Both Genders
Age Range 18-29
Notes for this study:
Inhalation of marijuana (800mg of 5.5% or 6.2% THC) in a placebo controlled study every other day for 3-6 weeks in regular marijuana users, assessing a variety of puff counts to assess dose-dependent effects, noted that subjective highs and stimulation were not dose-related although craving for marijuana was reduced with more puffs.

Relative to placebo there were reductions in psychomotor performance (DSST) and immediate but not delayed recall (DRT), with other cognitive parameters not affected.