Explorative Placebo-Controlled Double-Blind Intervention Study With Low Doses Of Inhaled Δ9-Tetrahydrocannabinol And Cannabidiol Reveals No Effect On Sweet Taste Intensity Perception And Liking In Humans
|Values||Ratings of fullness were higher after taking high-CBD cannabis compared to high-THC cannabis, but neither were significantly different from the placebo group.|
|Trial Design||Randomized trial|
|Trial Length||24 hours|
|Number of Subjects||10|
In this crossover trial, participants underwent three test conditions, in random order: In one, they inhaled vaporized cannabis containing about 4 mg THC and 25 mg CBD; in another, they inhaled vaporized cannabis containing about 1 mg THC and 10 mg CBD; in another, they inhaled placebo cannabis with no THC or CBD.
The participants were given seven chocolate milk drinks with 2, 4.4, 6.7, 10, 15, 22.5, and 33.8 g of sucrose per 100 mL. After tasting each, in random order, they were asked to rank their perception of the drinks' sweetness.
Additionally, three times during the sessions the participants rated their levels of hunger, fullness, desire to eat, and prospective consumption using a visual analogue scale. They were also given 1 L of their favorite drink to consume _ad libidum_.
Lastly, the participants were presented with pictures of foods with varying levels of energy, fat, protein, and carbohydrates, and were sweet or savory. The participants were then asked to rate their preference for each food.