Acute And Residual Mood And Cognitive Performance Of Young Adults Following Smoked Cannabis
| Effect | Decrease |
| Values | Cannabis consumption significantly worsened performance on the HVLT-R test, with the "high THC" group performing worse than the "low THC" group. This difference was present at 60 minutes, but not 24 or 48 hours. |
| Trial Design | Randomized trial |
| Trial Length | 1-7 Days |
| Number of Subjects | 91 |
| Sex | n/a |
| Age Range | 18-29 |
In this study, participants received either 12.5% or 0% THC cannabis by weight, in a 2:1 allocation ratio, to be consumed _ad libitum_ for 10 minutes. Blood samples, visual analogue scales scores, and vitals were collected at 5, 15, 30, 60, 120, 180, 240, 300, and 360 minutes post-administration. The participants then returned 24 and 48 hours later, during which they completed cognitive tasks and subjective effects scales and provided blood and urine samples. The outcomes measured were Profile of Mood States (POMS) score, Hopkins Verbal Learning Test-Revised (HVLT-R) score, Digit Symbol Substitution Test (DSST), Continuous Performance Test (CPT), Grooved Pegboard (GPB) task performance, and blood THC levels. Blood THC levels were used to sort THC users into "high" (≥7.3 ng/mL) and "low" (<7.3 ng/mL) groups.
