Studies related to Pain and Marijuana

Systematic Review And Meta-analysis Of Cannabis Treatment For Chronic Pain

Effect Decrease
Trial Design Meta analysis
Trial Length n/a
Number of Subjects 809
Gender Both Genders
Notes for this study:
Usage of marijuana or pure THC for the treatment of pain associated with chronic pain was noted to cause a significant reduction in pain when assessing 18 trials of 809 persons; the dose that alleviated pain was also the psychoactive dose, limiting usage in some people.

No publication bias reported.

Amygdala Activity Contributes To The Dissociative Effect Of Cannabis On Pain Perception

Effect Decrease
Trial Design Double blind
Trial Length 24 hours
Number of Subjects 12
Gender Male
Age Range 18-29, 30-44
Notes for this study:
In otherwise healthy subjects (naive to marijuana) where pain was induced by topical capsaicin and given either 15mg THC or placebo noted that the THC condition was associated with a reduction in perceived adverseness to the pain (despite the perception of pain intensity being similar); an overall benefit was seen due to subjects not caring about the pain as much.

Dose-dependent Effects Of Smoked Cannabis On Capsaicin-induced Pain And Hyperalgesia In Healthy Volunteers

Effect Decrease
Trial Design Double blind
Trial Length 24 hours
Number of Subjects 15
Gender Both Genders
Age Range 18-29, 30-44
Notes for this study:
Inhalation of marijuana in varying concentrations (2%, 4%, and 8% of marijuana being administered containing THC by weight) prior to an intradermal injection of capsaicin noted that after 45 minutes, but not after 5 minutes, there was a reduction in reported discomfort at the two higher doses in a dose-dependent manner but not the lower dose.

Lack Of Analgesia By Oral Standardized Cannabis Extract On Acute Inflammatory Pain And Hyperalgesia In Volunteers

Effect None
Trial Design Double blind
Trial Length 24 hours
Number of Subjects 18
Gender Female
Age Range 18-29
Body Types Average
Notes for this study:
In 18 otherwise healthy female volunteers who ingested 20mg THC with a meal and then were tested on various pain tests, there was a failure for THC to reduce pain in a capsaicin intradermal test (2.5 hours after ingestion) despite this being in the time range of peak plasma THC concentrations (2-4 hours). The pain associated with a sunburn test was also not affected any differently than placebo.

This dose of marijuana did not affect blood pressure (despite an increase in heart rate) and had psychoactive effects.