Effect of smoking marihuana and of a high-nicotine cigarette on angina pectoris
Notes for this study:
|Values||Seconds until exercise-induced angina. Control: 243.4 ±46.6 Cannabis: 124.1 ± 37.7|
|Number of Subjects||10|
This was a randomized open-label trial on 10 participants with classic stable exertional angina pectoris and evidence of severe coronary artery disease, who were smokers of tobacco cigarettes and whose angina was exercise-induced. The participants smoked 1 cannabis cigarette on 2 mornings and 1 high-nicotine cigarette on 2 morning while exercising on a cycle ergometer. Cannabis increased heart rate, systolic and diastolic blood pressure, and venous carboxyhemoglobin compared with not smoking and the baseline evaluation. There was notable decrease in time until angina onset when smoking cannabis compared with control and the nicotine cigarettes.