Studies related to Pain and Glucosamine

Glucosamine For Pain In Osteoarthritis: Why Do Trial Results Differ

Effect Decrease
Trial Design Meta analysis
Trial Length n/a
Number of Subjects 15
Gender n/a
Notes for this study:
Glucosamine hydrochloride failed to cause a significant protective effect in osteoarthritis, while evidence on sulfate (statistically significant of a low magnitude) was said to be confounded with industry influence. No publication bias reported

Glucosamine, Chondroitin Sulfate, And The Two In Combination For Painful Knee Osteoarthritis

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 1583
Gender Both Genders
Age Range 45-64, 65+
Notes for this study:
The GAIT trial noted that 1500mg Glucosamine in isolation failed to significantly influence a reduction of pain in persons with osteoarthritis over 6 months; combination therapy with Chondroitin was effective only in the cohort of persons with more pain at baseline

Glucosamine Sulfate Use And Delay Of Progression Of Knee Osteoarthritis: A 3-year, Randomized, Placebo-controlled, Double-blind Study

Effect Decrease
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 202
Gender Both Genders
Age Range 45-64, 65+
Body Types Overweight, Average
Notes for this study:
The progression of osteoarthritis associated with 1,500mg Glucosamine sulfate for 3 years appeared to be reduced as assessed by joint space loss relative to placebo and pain.

Glucosamine Sulfate In The Treatment Of Knee Osteoarthritis Symptoms: A Randomized, Double-blind, Placebo-controlled Study Using Acetaminophen As A Side Comparator

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 318
Gender Both Genders
Age Range 45-64
Body Types Overweight
Notes for this study:
1,500mg Glucosamine had equal efficay to 3g acetominophen for reducing joint pain in persons with osteoarthritis; this trial (the GUIDE trial) may be influenced by a producer of Glucosamine supplemnetation

Effectiveness Of Glucosamine For Symptoms Of Knee Osteoarthritis: Results From An Internet-based Randomized Double-blind Controlled Trial

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 205
Gender Both Genders
Age Range 45-64, 65+
Notes for this study:
(Internet based study) Mostly glucosamine sulfate, although a switch to hydrochloride for 20% of the sample was needed, failed to outperform placebo in regards to symptoms of osteoarthritis and pain.

Glucosamine Sulfate In Osteoarthritis Of The Knee

Effect Decrease
Trial Design Double blind
Trial Length n/a
Number of Subjects 252
Gender n/a
Notes for this study:
In persons with knee osteoarthritis, supplemental Glucosamine at 1,500mg daily for 4 weeks was associated with greater pain reduction than placebo and a greater response rate to treatment (55% relative to 38% for glucosamine and placebo, respectively)

Structural And Symptomatic Efficacy Of Glucosamine And Chondroitin In Knee Osteoarthritis: A Comprehensive Meta-analysis

Effect Decrease
Trial Design Meta analysis
Trial Length n/a
Number of Subjects 15
Gender n/a
Notes for this study:
A meta-analysis of 15 studies (inclusive of glucosamine and combination therapy of glucosamine with chondroitin; 7 studies used glucosamine sulfate) noted a significant effect on all measured outcomes of glucosamine treatment. Funnel plot analysis failed to find evidence of publication bias, although it appeared to trend close (and was said to be from influence from smaller studies with more effect size)

Effects Of Glucosamine, Chondroitin, Or Placebo In Patients With Osteoarthritis Of Hip Or Knee: Network Meta-analysis

Effect Decrease
Trial Design Meta analysis
Trial Length n/a
Number of Subjects 10
Gender n/a
Notes for this study:
A network meta-analysis on glucosamine sulfate found statistically significant pain relief, but deemed that the clinical significance of this pain relief was minimal.