Restoring Vascular Nitric Oxide Formation By L-arginine Improves The Symptoms Of Intermittent Claudication In Patients With Peripheral Arterial Occlusive Disease

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 39
Gender Both Genders
Age Range 45-64, 65+
Body Types Overweight
Notes for this study:
Supplementation of 8g of arginine twice daily (16g total) for 6 weeks in persons with intermittent claudication appears to promote blood flow and reduce symptoms associated with increased biomarkers of nitric oxide metabolite (nitrate and urinary cGMP). Functional testing noted that arginine outperformed 80mcg PGE1 in improving walking distance and pain-free walking distance, and improved VAS scores for symptoms.

L-arginine Supplementation In Peripheral Arterial Disease: No Benefit And Possible Harm

Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 133
Gender Both Genders
Age Range 65+
Notes for this study:
3g arginine daily for 6 months in persons with peripheral artery disease (intermittent claudication in this study) noted that supplementation was actually adverse to blood flow and symptoms of claudition as assessed by functional testing on a treadmill (reducing a 28.3% improvement to 11.5%).