Restoring Vascular Nitric Oxide Formation By L-arginine Improves The Symptoms Of Intermittent Claudication In Patients With Peripheral Arterial Occlusive Disease

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 39
Gender Both Genders
Age Range 45-64, 65+
Body Types Overweight
Notes for this study:
Supplementation of 8g of arginine twice daily (16g total) for 6 weeks in persons with intermittent claudication appears to promote blood flow and reduce symptoms associated with increased biomarkers of nitric oxide metabolite (nitrate and urinary cGMP). Functional testing noted that arginine outperformed 80mcg PGE1 in improving walking distance and pain-free walking distance, and improved VAS scores for symptoms.

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