Studies related to Blood Pressure and Arginine

Hemodynamic And Vascular Response To Resistance Exercise With L-arginine

Effect None
Trial Design Double blind
Trial Length 24 hours
Number of Subjects 17
Gender Male
Age Range 18-29
Body Types Overweight
Notes for this study:
Supplementation of 7g L-arginine prior to resistance training exercise failed to note significant differences in blood flow and pressure (a lone subset increased, although it was significantly lower at baseline; all other parameters were not influenced). Vascular resistance was unaffected.

Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance
Effect Decrease
Trial Design doubleblind
Trial Length 1week
Number of Subjects 9
Gender m
Notes for this study:
Supplemental arginine for 3 days at 6g, relative to placebo, was able to enhance nitric oxide production and decrease oxygen consumption (7%) while improving time to exhaustion (24.8%) in otherwise healthy men.

Effect Of A Long-term Oral L-arginine Supplementation On Glucose Metabolism: A Randomized, Double-blind, Placebo-controlled Trial

Effect Decrease
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 144
Gender Both Genders
Age Range 45-64, 65+
Body Types Obese
Notes for this study:
In persons with impaired glucose tolerance where 6.4g L-arginine was given daily for 18 months (followed by 12 months of followup), supplementation was associated with improved fat mass and lean mass (increase in lean mass was 0.12+/-1.97, and only statistically significant when compared to the loss seen with placebo) and associated with improved insulin secretion following a test meal. Insulin sensitivity increased by Strumvall but not HOMA-IR, and fasting blood flow and glucose were unaltered.

L-arginine-induced Vasodilation In Healthy Humans: Pharmacokinetic-pharmacodynamic Relationship

Effect None
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 8
Gender Male
Age Range 18-29
Body Types Average
Notes for this study:
Infusions of arginine were able to reduce blood pressure without affecting heart rate, but 6g oral supplementation failed to replicate these effects.

Effects Of 7 Days Of Arginine-alpha-ketoglutarate Supplementation On Blood Flow, Plasma L-arginine, Nitric Oxide Metabolites, And Asymmetric Dimethyl Arginine After Resistance Exercise

Effect None
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 24
Gender Male
Age Range 18-29
Body Types Trained, Average
Notes for this study:
7 days supplementation of Arginine AAKG at 12g daily in physically active men failed to influence blood pressure/flow or heart rate and also failed to influence either nitric oxide metabolites or ADMA.