Studies related to HbA1c and Arginine

Effect Of A Long-term Oral L-arginine Supplementation On Glucose Metabolism: A Randomized, Double-blind, Placebo-controlled Trial

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 144
Gender Both Genders
Age Range 45-64, 65+
Body Types Obese
Notes for this study:
In persons with impaired glucose tolerance where 6.4g L-arginine was given daily for 18 months (followed by 12 months of followup), supplementation was associated with improved fat mass and lean mass (increase in lean mass was 0.12+/-1.97, and only statistically significant when compared to the loss seen with placebo) and associated with improved insulin secretion following a test meal. Insulin sensitivity increased by Strumvall but not HOMA-IR, and fasting blood flow and glucose were unaltered.

The Effect Of Oral L-arginine Supplementation On Fasting Glucose, HbA1c, Nitric Oxide And Total Antioxidant Status In Diabetic Patients With Atherosclerotic Peripheral Arterial Disease Of Lower Extremities

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 38
Gender Both Genders
Age Range 45-64, 65+
Body Types Obese, Overweight
Notes for this study:
6g of L-Arginine daily (in three doses of 2g) for 2 months in persons with both diabetes and peripheral artery disease was able to increase total antioxidant capacity (normally impaired with diabetes) and nitric oxide metabolites, but failed to benefic HbA1c and fasting blood glucose.