Studies related to Insulin Secretion and Arginine

Effect Of A Long-term Oral L-arginine Supplementation On Glucose Metabolism: A Randomized, Double-blind, Placebo-controlled Trial

Effect Increase
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 144
Gender Both Genders
Age Range 45-64, 65+
Body Types Obese
Notes for this study:
In persons with impaired glucose tolerance where 6.4g L-arginine was given daily for 18 months (followed by 12 months of followup), supplementation was associated with improved fat mass and lean mass (increase in lean mass was 0.12+/-1.97, and only statistically significant when compared to the loss seen with placebo) and associated with improved insulin secretion following a test meal. Insulin sensitivity increased by Strumvall but not HOMA-IR, and fasting blood flow and glucose were unaltered.