Studies related to Blood Flow and Arginine

Hemodynamic And Vascular Response To Resistance Exercise With L-arginine

Effect None
Trial Design Double blind
Trial Length 24 hours
Number of Subjects 17
Gender Male
Age Range 18-29
Body Types Overweight
Notes for this study:
Supplementation of 7g L-arginine prior to resistance training exercise failed to note significant differences in blood flow and pressure (a lone subset increased, although it was significantly lower at baseline; all other parameters were not influenced). Vascular resistance was unaffected.

Pharmacokinetic And Pharmacodynamic Properties Of Oral L-citrulline And L-arginine: Impact On Nitric Oxide Metabolism

Effect Increase
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 20
Gender Both Genders
Age Range 45-64, 65+
Body Types Overweight, Average
Notes for this study:
Supplemental L-arginine (3g twice a day) was able to increase nitric oxide metabolites without significantly affecting blood flow. ADMA was not increased (the arginine:ADMA ratio actually increased).

Effect Of A Long-term Oral L-arginine Supplementation On Glucose Metabolism: A Randomized, Double-blind, Placebo-controlled Trial

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 144
Gender Both Genders
Age Range 45-64, 65+
Body Types Obese
Notes for this study:
In persons with impaired glucose tolerance where 6.4g L-arginine was given daily for 18 months (followed by 12 months of followup), supplementation was associated with improved fat mass and lean mass (increase in lean mass was 0.12+/-1.97, and only statistically significant when compared to the loss seen with placebo) and associated with improved insulin secretion following a test meal. Insulin sensitivity increased by Strumvall but not HOMA-IR, and fasting blood flow and glucose were unaltered.

Restoring Vascular Nitric Oxide Formation By L-arginine Improves The Symptoms Of Intermittent Claudication In Patients With Peripheral Arterial Occlusive Disease

Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 39
Gender Both Genders
Age Range 45-64, 65+
Body Types Overweight
Notes for this study:
Supplementation of 8g of arginine twice daily (16g total) for 6 weeks in persons with intermittent claudication appears to promote blood flow and reduce symptoms associated with increased biomarkers of nitric oxide metabolite (nitrate and urinary cGMP). Functional testing noted that arginine outperformed 80mcg PGE1 in improving walking distance and pain-free walking distance, and improved VAS scores for symptoms.

Effects Of 7 Days Of Arginine-alpha-ketoglutarate Supplementation On Blood Flow, Plasma L-arginine, Nitric Oxide Metabolites, And Asymmetric Dimethyl Arginine After Resistance Exercise

Effect None
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 24
Gender Male
Age Range 18-29
Body Types Trained, Average
Notes for this study:
7 days supplementation of Arginine AAKG at 12g daily in physically active men failed to influence blood pressure/flow or heart rate and also failed to influence either nitric oxide metabolites or ADMA.

L-arginine Supplementation In Peripheral Arterial Disease: No Benefit And Possible Harm

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 133
Gender Both Genders
Age Range 65+
Notes for this study:
3g arginine daily for 6 months in persons with peripheral artery disease (intermittent claudication in this study) noted that supplementation was actually adverse to blood flow and symptoms of claudition as assessed by functional testing on a treadmill (reducing a 28.3% improvement to 11.5%).