Pharmacokinetic And Pharmacodynamic Properties Of Oral L-citrulline And L-arginine: Impact On Nitric Oxide Metabolism

Effect None
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 20
Gender Both Genders
Age Range 45-64, 65+
Body Types Overweight, Average
Notes for this study:
Supplemental L-arginine (3g twice a day) was able to increase nitric oxide metabolites without significantly affecting blood flow. ADMA was not increased (the arginine:ADMA ratio actually increased).

Effects Of 7 Days Of Arginine-alpha-ketoglutarate Supplementation On Blood Flow, Plasma L-arginine, Nitric Oxide Metabolites, And Asymmetric Dimethyl Arginine After Resistance Exercise

Effect None
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 24
Gender Male
Age Range 18-29
Body Types Trained, Average
Notes for this study:
7 days supplementation of Arginine AAKG at 12g daily in physically active men failed to influence blood pressure/flow or heart rate and also failed to influence either nitric oxide metabolites or ADMA.

L-arginine Supplementation In Peripheral Arterial Disease: No Benefit And Possible Harm

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 133
Gender Both Genders
Age Range 65+
Notes for this study:
3g arginine daily for 6 months in persons with peripheral artery disease (intermittent claudication in this study) noted that supplementation was actually adverse to blood flow and symptoms of claudition as assessed by functional testing on a treadmill (reducing a 28.3% improvement to 11.5%).