Influence Of Adjuvant Coenzyme Q10 On Inflammatory And Oxidative Stress Biomarkers In Patients With Bipolar Disorders During The Depressive Episode
Notes for this study:
||Mean and SD. Placebo: before 1.48 (0.24) , after 1.36 (.29). Intervention: before 1.53 (0.29), after 1.14 (0.32).
|Number of Subjects
In a randomized, double-blind, placebo-controlled trial, 89 participants with bipolar disorder undergoing a depressive episode were allocated to take 200 mg/d of coq10 or placebo daily in addition to their usual medication for 8 weeks.
69 participants completed the study and were analyzed. Tumor necrosis factor and IL-10, were reduced significantly more with coq10 than placebo, and total antioxidant capacity and total thiol groups increased significantly more. There was a nonsignificant reduction in nitric oxide and malondialdehyde, increase in catalase activity, and no notable difference for IL6.