Studies related to Lipid Peroxidation and Coenzyme Q10

Oxidative Stress Correlates With Headache Symptoms In Fibromyalgia: Coenzyme Q₁₀ Effect On Clinical Improvement

Effect Decrease
Trial Design Double blind
Trial Length n/a
Number of Subjects 20
Gender n/a
Notes for this study:
CoQ10 supplementation in a population of persons with fibromyalgia given 300mg daily for 3 months was able to reduce levels of lipid peroxidation and pro-oxidative markers in the serum, and vicariously though this (hypothesized due to correlations) reductions were seen in headaches associated with fibromyalgia by correcting abnormal markers of metabolism.

Reversal Of Mitochondrial Dysfunction By Coenzyme Q10 Supplement Improves Endothelial Function In Patients With Ischaemic Left Ventricular Systolic Dysfunction: A Randomized Controlled Trial

Effect Decrease
Trial Design Double blind
Trial Length n/a
Number of Subjects 56
Gender n/a
Notes for this study:
In persons with ischaemic left ventricular systolic dysfunction given 300mg CoQ10 daily for 8 weeks, an improvement in blood flow from endothelial function was seen and possibly was due to a reduction in lipid peroxidation (as assessed by correlation, causation not shown).

No effects on markers of diabetic health or other markers of heart health were seen.

Coenzyme Q10 Improves Seminal Oxidative Defense But Does Not Affect On Semen Parameters In Idiopathic Oligoasthenoteratozoospermia: A Randomized Double-blind, Placebo Controlled Trial

Effect Decrease
Trial Design Double blind
Trial Length n/a
Number of Subjects 47
Gender n/a
Notes for this study:
In persons with idiopathic oligoasthenoteratozoospermia (basically bad sperm quality resulting in infertility), usage of 200mg of CoQ10 daily for 12 weeks was associated with a reduction in oxidative stress as measured in the semen, but did not increase any parameters of the semen such as motility or count.

Effects Of Coenzyme Q10 Supplementation On Liver Mitochondrial Function And Aerobic Capacity In Adolescent Athletes

Effect Decrease
Trial Design Double blind
Trial Length n/a
Number of Subjects 18
Gender n/a
Notes for this study:
After supplementation of 100mg CoQ10 daily, serum levels of CoQ10 were increased while they were decreased in the placebo group due to exercise. Normalized oxidation rates were seen with CoQ10 while increases in oxidation and lipid peroxidation were seen in placebo.

Despite the above beneficial trends, no significant effects on exercise performance were noted.