Hormonal And Metabolic Effects Of Coenzyme Q10 And/or Vitamin E In Patients With Polycystic Ovary Syndrome
Notes for this study:
||Mean and SD.. Placebo: before 1.62 ± 0.99, after 1.60 ± 1.12 . Coq10: before 1.88 ± 0.91 , after 2.35 ± 1.13 . Vitamin E: before 1.80 ± 0.86 , after 2.46 ± 1.02 . Combination: before 1.78 ± 0.78, after 2.27 ± 1.08 .
|Number of Subjects
In a randomized, double-blind, placebo-controlled trial, 86 participants with polycystic ovary syndrome were allocated to take placebo, 200 mg of coq10, 400 IU of vitamin E, or the combination daily for 8 weeks.
Progesterone level was the primary outcome, and there was a notable increase in the coq10 group but not the placebo group. There was also a considerable increase in estradiol, a decrease in testosterone, an increase in sex hormone-binding globulin, and a reduction in luteinizing hormone, with no change follicle-stimulating hormone. There was a statistically significant reduction in fasting blood sugar, insulin, and insulin resistance, which was greater than placebo.