Hormonal And Metabolic Effects Of Coenzyme Q10 And/or Vitamin E In Patients With Polycystic Ovary Syndrome

Effect Increase
Values Median and 25th-75th percentiles. Placebo: before 42.30 (25.20, 56.80) , after 40.80 (31.00, 44.50). Coq10: before 27.65 (16.37,68.20), after 41.05 (26.40, 71.20) . Vitamin E: before 38.00 (25.32, 72.50) , after 54.10 (31.50,66.20) . Combination: before 27.60 (21.85, 40.05), after 50.30 (33.00,86.95).
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 86
Sex Female
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 86 participants with polycystic ovary syndrome were allocated to take placebo, 200 mg of coq10, 400 IU of vitamin E, or the combination daily for 8 weeks.

Progesterone level was the primary outcome, and there was a notable increase in the coq10 group but not the placebo group. There was also a considerable increase in estradiol, a decrease in testosterone, an increase in sex hormone-binding globulin, and a reduction in luteinizing hormone, with no change follicle-stimulating hormone. There was a statistically significant reduction in fasting blood sugar, insulin, and insulin resistance, which was greater than placebo.