Coenzyme Q10 Supplementation Reduces Oxidative Stress And Decreases Antioxidant Enzyme Activity In Children With Autism Spectrum Disorders

Effect Increase
Values Total antioxidant status. Mean and Sd. (mM). Placebo: MDA. Placebo: before 0.16 (0.08) , after 0.16 (0.05). Low dose: before 0.09 (0.047) , after. High dose: before 0.07 (0.02), after 0.14 (0.04).
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 78
Sex Both Genders
Age Range 1-6, 7-12
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 78 children with mild to severe autism spectrum disorders took a placebo, 30 mg or 60 mg of coenzyme q10 daily for 100 days.

There was a statistically significant reduction in malondialdehyde, increase in total antioxidant status, superoxide dismutase activity, and glutathione peroxidase activi in the 60 mg group but not the 30 mg or placebo groups.

Gastrointestinal problems improved in more participants in the 60 mg groups, while there was no notable difference for 30 mg compared with placebo, and the same goes for sleep disorders, but not sociability or verbal communication.

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