Studies related to Serum Cobalamin and Trimethylglycine

Effect of Folic Acid and Betaine Supplementation on Flow-Mediated Dilation: A Randomized, Controlled Study in Healthy Volunteers
Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 39
Sex Both Genders
Age Range 45-64, 65+
Body Types Overweight
Notes for this study:
Six weeks supplementation of 6g TMG in otherwise healthy adults (aged 50-70) was sufficient to lower fasting plasma homocysteine (12%) which underperformed relative to 800mcg folic acid; blood flow was unaffected. Serum B12 was not affected relative to placebo, but due to a nonsignificant drop in folate and a nonsignificant rise in the TMG group there was a difference between them.

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